Hongjitang's Smart Traditional Chinese Medicine deepens the path of production, education, research, medical treatment, and standard research, constructing the research system platform of the Hongjitang Central Research Institute. The institute includes the Jinan Research Institute, Hengqin Research Institute, Macao Research Institute, Functional Food Research Institute, among others. It has actively and effectively explored various dimensions such as innovative drug research and development, development of classic Chinese medicine prescriptions, construction of comprehensive evaluation systems for traditional Chinese medicine preparations, and research and development of traditional Chinese medicine formula granules. In 2022, Hongjitang Pharmaceutical was awarded the National Enterprise Technology Center.

The institute has academicians, national master physicians, and nationally renowned studios for traditional Chinese medicine. It has established cooperative relationships with several renowned universities, focusing on advantageous areas such as the respiratory system, cardiovascular and cerebrovascular systems, urogenital system, pediatrics, geriatrics, etc. It conducts research and development of innovative Chinese herbal medicines and improved new drugs with clinical efficacy advantages and characteristics; it conducts cultivation of major varieties, focusing on clarifying clinical positioning and reevaluation, clarifying mechanism of action research, improving product quality and scientific value, and actively promoting the creative transformation and innovative development of traditional Chinese medicine culture.

The institute has more than 70 research and development personnel, including 8 doctors, with over 80% holding master's degrees. It has a research and development area of 3600 square meters and a pilot plant of 700 square meters, equipped with a batch of advanced experimental instruments and equipment such as HPLC, LC-MS, ICP-MS. The pilot plant is equipped with more than 20 pilot equipment imported from Japan for extraction, concentration, and formulation, with superior experimental conditions and working environment, providing guarantees for the smooth progress of projects. Hongjitang Pharmaceutical emphasizes research and development, with research and development investment accounting for more than 4% for consecutive years.